In the meantime, do check out what Prof Yaseen Arabi has to say about trial designs in the ICU for infectious diseases!
He was behind the MIRACLE trial – the first RCT for MERS treatment, looking at the combination of lopinavir/ritonavir and interferon-β1b back when MERS emerged.
Fast-forward to 2020, Prof Yaseen Arabi discusses the quick modifications made to the international REMAP-CAP Trial to accommodate COVID-19 – now termed REMAP-COVID.
Check out some of his articles here:
NEJM Special Report: Middle East Respiratory Syndrome
COVID-19: a novel coronavirus and a novel challenge for critical care