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COVID-19 ICU Trials MERS

Trial Designs

In the meantime, do check out what Prof Yaseen Arabi has to say about trial designs in the ICU for infectious diseases!

He was behind the MIRACLE trial – the first RCT for MERS treatment, looking at the combination of lopinavir/ritonavir and interferon-β1b back when MERS emerged.

Fast-forward to 2020, Prof Yaseen Arabi discusses the quick modifications made to the international REMAP-CAP Trial to accommodate COVID-19 – now termed REMAP-COVID.

Check out some of his articles here:

NEJM Special Report: Middle East Respiratory Syndrome

Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial

COVID-19: a novel coronavirus and a novel challenge for critical care

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